3D Printing of Organs?
The total loss or functional failure of a tissue or an organ is one of the most devastating, important and costly problem in human healthcare. There is an overwhelming need for substitutes to replace or repair tissues or organs because of disease, trauma, or congenital problems. More than $500 billion is spent each year on patients suffering from organ failure or tissue loss. Traditionally, the damaged or diseased tissues are regenerated using complex mold-like structures called tissue scaffolds. Tissue scaffolds are complex structures that help tissue cells to form the final shape of the tissue that meets the replaced tissue’s biological and physical requirements. Recently, direct 3D printing of cells (bioink) along with biomaterials are being considered forefront research work to achieve 3D printing of organs. In this presentation, computational bio-modeling methods will be presented to bio-mimetically design fully customized and complex three-dimensional (3D) heterogeneous (multi-material) scaffold structures with controlled material composition and distribution. The computational methods will be explained in modeling of “active” bio-structures which can satisfy different and sometimes conflicting biological and mechanical functional requirements of tissue scaffolds. The presentation will then introduce a novel design and path planning for 3D printing of cell aggregates (bioink) with hydrogel support material towards 3D printing of tissues and organs.
Bahattin Koç received his Ph.D. and M.S. degrees in Industrial Engineering from North Carolina State University in 2001 and 1997 respectively and his B.S. degree in Industrial Engineering from Istanbul Technical University, Istanbul, Turkey in 1993. He was an Associate Professor of Industrial and Systems Engineering at the University at Buffalo (SUNY) before joining to Sabancı University in 2010. His research interests include Tissue Engineering, Additive Manufacturing, Computational geometry for design and manufacturing, Nano/micro manufacturing, CAD/CAM integration.