UNCOVERING ICL1 NETWORK UNDER HYPOXIC STRESS RESPONSE IN M. TUBERCULOSIS
Department of Bioengineering, Rice University
Mycobacterium tuberculosis responds to stress encountered during infection by arresting multiplication and undergoing major metabolic remodeling leading to dormancy. The metabolic genes gltA1 andicl1 are controlled by the sigma factor E (σE) and they are induced in response to adaptive immunity in the lungs of infected mice. We investigate the relationships between the network architecture and underlying dynamics for σE network to explain nonmonotonic kinetics of induction of these central metabolism genes under hypoxic stress. Model predicted negative regulator in the network is tested and verified experimentally.
About the Speaker: Baris Hancioglu received his B.S. degree from Bilkent University Mathematics Department, and he received his Ph.D degree from University of Pittsburgh in 2007. He worked at Merck & CO, Inc. as a Co-Op and at Prof. Tyson’s Lab at Virgina Tech Department of Biology as a Postdocroral Researcher. He is currently a Postdoctoral Fellow at Prof. Igoshin’s Lab at Department of Bioengineering at Rice University. His research interests lie in the area of Bioinformatics/Computational Systems Biology. He uses methods of nonlinear dynamics, statistics, bioinformatics and theoretical biophysics methods to quantitatively characterize the design and behavior of biochemical networks. He closely collaborates with experimental researchers to design experiments to test models and theories.