Structural Plasticity at Single Inputs following Naturalistic Activity..
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Structural Plasticity at Single Inputs following Naturalistic Activity Patterns

Ali Özgür Argunşah 
Champalimaud Neuroscience Programme (CNP)
Lisbon, Portugal


Thursday, December 17, 9:40-10:30
FENS 2072
 
Naturally occurring patterns of activity are complex in structure and have an irregular distribution of action potentials. It is unclear what forms of plasticity results from these various patterns from such activity at individual inputs. Using two-photon glutamate uncaging, we deliver various defined patterns of activity at individual inputs on single dendritic spines in CA1 region of hippocampus and follow the structural correlates over short and long time scales in living neurons. These stimulations are based on activity recorded in vivo from hippocampal area CA3 during a behavioral task. We compare the structural consequences of such irregular patterns of activity to regularly spaced activity trains.

Bio: Ali is a Ph.D. candidate in neuroscience at the Champalimaud Neuroscience Programme (CNP), in Lisbon, Portugal. He studied biomedical engineering in Baskent University and did his masters in Sabanci University, working on developing machine-learning algorithms for EEG based brain computer interfaces under the supervision of Prof. Mujdat Cetin. During his graduate studies, he worked as a visiting researcher on epilepsy signal analysis and in-vivo recordings at Massachusetts General Hospital with Emery N. Brown and RIKEN BSI with Thomas J. McHugh, respectively. Ali is currently working on understanding the mechanism of memory formation and storage through plasticity processes by using techniques such as two photon imaging, glutamate uncaging and patch clamp electrophysiology.