Title: Seminar on Malaria Research from Singapore University of Tech. & Design
Speaker: Dr Rajesh Chandramohanadas
Date/Time: 30 November 2015, 13:00
Place: FENS G029
Abstract: Malaria infection causes significant morbidity and mortality worldwide. Efforts to control this deadly disease include insect vector elimination or the development of small molecule inhibitors that can impair asexual development of the pathogen. However, emergence of rapid/progressive drug resistance necessitates the discovery of novel therapeutic targets and life-stage events for the development of new lines of chemotherapy. Chandramohanadas laboratory at SUTD focuses on establishing complex host-pathogen interactions during egress and invasion of malaria parasites as suitable check-points for drug development by integrating state of the art platforms for cell- biomechanics, proteomics, chemical biology and computational biology. In this lecture, viability of this approach to discover novel drug targets, of both host (Science 2009, MCP 2011) and parasitic origin (JID 2014) will be discussed. Furthermore, data validation steps using cell biomechanics (PLoS ONE 2011, Scientific Reports 2015) and computational docking will be highlighted (JID 2014). Application of engineering tools in discovery biology and its viability in facilitating translation, in the form of hitherto unexplored therapeutic and diagnostic approaches will be summarized.