Faculty of Engineering and Natural Sciences
Quest for Finding Novel Regulators of Neural Development
Center, Department of Cell Biology,
Multipotent neural stem cells (NSCs) in the central nervous system are capable of self-renewal and can also give rise to neurons, astrocytes, and oligodendrocytes. Sox2 is expressed in neural precursors and neural stem cells and is important for the proliferation and maintenance of NSCs, and the maintenance of neurons in specific brain regions. In humans, mutations in Sox2 cause an Anophthalmia syndrome that includes brain malformation, epileptic seizures, motor abnormalities and learning difficulties. However, little is known on its interactor proteins or the mechanism through which Sox2 performs its functions. We recently identified interactors and targets of Sox2 to improve our understanding of the mechanisms that control the balance between neural stem cell maintenance and differentiation.
December 17, 2008, 13:40, FENS L048