Magnetic Resonance Spectroscopic Imaging of Brain Tumors at 3T and 7T
Dr. Esin Öztürk Işık
Radiology and Biomedical Imaging Dept
UCSF, CA, USA
The American Cancer Society estimates that 210,800 malignant tumors of the brain or spinal cord will be diagnosed worldwide and 130,000 people will die from these tumors during 2009. Magnetic resonance imaging (MRI) provides a valuable diagnostic tool to localize brain tumors. Although anatomical MR imaging has brought significant advances in diagnostic imaging, it sometimes provides limited or ambiguous information regarding the tissue function. Addition of 3D magnetic resonance spectroscopic imaging (MRSI) to the anatomical MR imaging for patients diagnosed with brain tumors has been shown to provide better brain tumor localization, treatment planning, and assessment of treatment response. 3D MRSI has been successfully employed to extract information about brain tumor cellularity, cell membrane breakdown, cellular energetics, and neuronal activity through its ability to differentiate signals coming from choline (Cho), creatine (Cr), N-acetyl aspartate (NAA), lipid and lactate molecules. Two major problems of the MRSI are the long minimum data acquisition time and its susceptibility to magnetic field inhomogeneities. In this talk, fast data acquisition and reconstruction techniques will be presented along with another method to reduce the field inhomogeneity effects. The application of these methods will be presented on 3T and 7T high field MR scanners.
Bio: Esin Öztürk Işık, Ph.D. completed her Bachelor's studies in the Computer Engineering department of the Middle East Technical University in 1999. She attended the Biomedical Engineering program at the University of Alabama at Birmingham. She finished her thesis studies on the development of regularization methods for magnetic resonance imaging (MRI) data reconstruction under the guidance of Donald B. Twieg, Ph.D. and received her Master's degree from UAB in 2002. Thereafter Dr. Öztürk Işık was admitted to the joint Bioengineering program between the University of California at Berkeley and the University of California at San Francisco. She joined the Margaret Hart Surbeck Laboratory of Advanced Imaging to work with Sarah J. Nelson, Ph.D. The goal of her thesis research was to implement several fast MRI and magnetic resonance spectroscopic imaging (MRSI) data acquisition and reconstruction techniques for faster and more accurate spectral quantification of brain tumors using the clinical 3T MR scanners. Dr. Öztürk Işık completed her Ph.D. studies in 2007 and has continued her research as a postdoctoral fellow in the Radiology and Biomedical Imaging department at UCSF. Her postdoctoral research studies have included the implementation and optimization of higher resolution and sensitivity MRSI techniques on the whole body high field 7T MRI scanners.
July 8, 2009, 13:40, FENS 2019