CS Seminar by Atilla Gursoy (27 May 2011, 13:40, FENS L065)
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  • CS Seminar by Atilla Gursoy (27 May 2011, 13:40, FENS L065)

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Sabancı University
Faculty of Engineering and Natural Sciences
CS Seminar
Friday, 27 May 2011 at 13:40
Large-scale prediction of computational hot spots and their use in targeting and
predicting protein-protein interactions
Atilla Gürsoy
Koc University

Protein-protein interactions are critical in the vast majority of biological processes. Cellular
dysfunction via faulty non-native interactions is the cause of many diseases. Protein
interactions are mediated by interfaces, which are large and flat regions on the protein
surface that have generally not been considered druggable However, studies have
revealed that drugs can target protein-protein interfaces at key contact regions called "hot
spots". In this talk, I'll present computational approaches to predict hot spots and regions,
and their application in predicting protein interactions at proteomics level.
Attila Gursoy is a professor of Computer Science at Koc University, Istanbul, Turkey. He
received the BS degree from Middle East Technical University, Ankara, Turkey, the MS
degree from Bilkent University, Ankara, Turkey, both in Computer Engineering in 1986 and
1988. He received the PhD degree from University of Illinois at Urbana-Champaign in
Computer Science in parallel computing in 1994. He worked in the Theoretical Biophysics
Group in Beckman Institute, University of Illinois as a postdoctoral research associate
where Dr. Gursoy contributed significantly to the design and development of NAMD, a
popular parallel molecular dynamics simulation program. Dr. Gursoy's research is in the
area of computational biology, particularly protein-protein interactions, protein-interaction
networks, and integration of structural information at the system level. He is co-leading
COSBI (Computational and Systems Biology) Group at Koc university.