Transcription Factors That Control Interleukin-7 Receptor Gene Expression
Interleukin-7 Receptor is a critical cytokine receptor for T-lymphocytes that controls differentiation and survival. We have identified several transcription factors that bind to various control regions of the IL-7R gene that control gene expression. Among these are PU.1 and GABP that bind to the promoter, the inhibitory transcription factor Gfi-1 that binds an evolutionarily conserved region in the second intron of the IL-7R gene, and FoxP3, that binds to an enhancer 3.5kb before the transcription start site of this gene. We have studied the transcription factors mediating the transcription of the IL-7R gene upon stimulation by the glucocorticoid dexamethasone. Analysis of the differences in the expression patterns of genes by Nimblegen microarrays indicate that other genes of importance to T lymphocytes may be coordinately regulated with IL-7R.