Optical Coherence Tomography for Neuroimaging
Taner Akkın, Ph.D.
Department of Biomedical Engineering, University of Minnesota
Research in my laboratory involves development and use of multi-contrast optical coherence tomography techniques to visualize tissue microstructure and function with high spatiotemporal resolution. We demonstrated that imaging with retardance and optic axis orientation contrasts is valuable for distinguishing between white matter and gray matter in the brain, and for visualizing nerve fiber tracts that are as small as a few tens of micrometers (optical tractography). Since the functional recovery of neural tissue may be possible only when the tissue structure is intact, detecting structural changes during physiological activity prior to any structural loss or permanent damage is the main thrust of our work. I will present depth-resolved detection of neural activity (action potentials) in nonmyelinated axons with and without voltage-sensitive dyes. With further investigation these results could open a new era in functional imaging technology to localize neural activity at different depths in situ.
Biography: Taner Akkın, Ph.D., is an Assistant Professor in the Department of Biomedical Engineering at the University of Minnesota. After receiving BS and MS degrees from Çukurova University in Turkey, Dr. Akkın received his Ph.D. degree from The University of Texas at Austin in 2003. His postdoctoral work was at Wellman Center for Photomedicine at Massachusetts General Hospital and Harvard Medical School, where he was appointed as an instructor before joining University of Minnesota in 2005.
December 28, 2011, 14:40, FENS G032