Motor Protein-based Nano Transport System Utilizing MEMS Tweezers
  • FENS
  • Motor Protein-based Nano Transport System Utilizing MEMS Tweezers

You are here

MAT Program Fall 2011-2012 Seminar Series
Motor Protein-based Nano Transport System Utilizing MEMS Tweezers

M. Cagatay Tarhan
University of Tokyo

Motor proteins are nanometer-sized molecular machines that convert chemical energy derived
from ATP hydrolysis to mechanical work. Intracellular transport is based on motor protein
motion along rail structures called microtubules. In vitro reconstruction of intracellular
transport has a potential to alleviate the handling challenges caused by the scaling down
technology. Kinesin, a linear motor protein, can be used as a carrier to transport tiny amount
of materials in a nano-scale microfluidic device. This talk focuses on combining top-down
fabrication and handling capabilities of MEMS technology with bottom-up functionalities of
the bio-world. Sorting and transport of target molecules using motor function and molecular
recognition will be explained. Furthermore, an innovative method to build multidirectional
and multilayered assembly of microtubule network using MEMS tweezers will be introduced.
Finally, a possible future direction of such heterogeneous integrated systems, i.e. bio/MEMS
hybrid system will be investigated as a potential molecular detection system that can lead to a
device for neurodegenerative disease diagnosis.


Friday, 27 January 2012, 14.00