High-Resolution Diffusion MRI / Magnetic Particle Imaging
Emine U. Saritas
University of California, Berkeley
Abstract: Diffusion MRI is a magnetic resonance imaging (MRI) method that provides information about random microscopic motion of water molecules in biological tissues. In addition to providing a higher sensitivity for the diagnosis of white matter related diseases such as stroke and multiple sclerosis, and producing connectivity maps of the brain, it is a promising prognostic tool in the assessment and treatment response monitoring of cancer in the body.
While high in-plane resolution is desirable for all diffusion MRI applications, it is particularly essential for the diffusion-weighted imaging (DWI) of small structures. In the first part of this talk, I will present advanced pulse sequence methods to overcome the problems associated with and enable high-resolution diffusion MRI of targeted regions. In addition to validating the performance of the proposed methods outside the central nervous system, example cases from an extensive clinical evaluation of the high-resolution diffusion MRI of spinal cord will be presented.
In the second part of my talk, I will introduce magnetic particle imaging (MPI): a new and powerful imaging modality with high contrast, high resolution and high sensitivity in detecting the spatial distribution of magnetic tracers in animals and human body. MPI exploits the nonlinear response of super-paramagnetic iron oxide nanoparticles to oscillating magnetic fields. With application ranging from in vivo stem cell tracking to angiography, MPI promises superior contrast and sensitivity over existing medical imaging modalities.
BIO: Emine Ülkü Sarıtaş graduated with a B.S. degree in Electrical & Electronics Engineering from Bilkent University in 2002. She received her Ph.D. degree in Electrical Engineering at Stanford University in 2009, working under the supervision of Prof. Dwight Nishimura on high-resolution diffusion magnetic resonance imaging. She is currently a postdoctoral fellow in Prof. Steven Conolly’s Imaging Systems Lab in the Department of Bioengineering at the University of California, Berkeley. Her current research focuses on the development of magnetic particle imaging techniques, as well as their safety and image reconstruction algorithms.