We are hosting Dr. Nurhan Ozlu from Koc University. Please find below the abstract.
location: fens L067
Cell division from a proteomic perspective
Cell division requires coordinated activities of different cellular machineries such as the microtubule cytoskeleton, actin cytoskeleton and membrane compartments. During mitosis the cell undergoes very dramatic changes in its structure and biochemical state in a short period of time. A Mass Spectrometry and SILAC (Stable Isotope Labeling with Amino acids in Cell culture) based quantitative proteomic approach will be presented that aims to understand how phosphorylation dynamics and cytoskeleton proteins change as cells move from mitosis (M-phase) into cytokinesis (C-phase) in mammalian cells. This analysis revealed that Aurora B kinase is a master regulator of the cytoskeleton during C-phase and dramatic switching of binding partners by Aurora B is an important regulatory mechanism in M-phase to C-phase transition.