New Technologies Towards Quantitatively Accurate Optical Molecular
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  • New Technologies Towards Quantitatively Accurate Optical Molecular

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Physics Seminar

Speaker:        Prof. Gultekin Gulsen,
                      Tu and Yuen Center for Functional Onco-Imaging,
                      Depts. of Radiology, BME, Physics, EECS
                      Director, Division of Optical Imaging, Dept. of Radiology
                      Director, In-vivo Functional Onco-Imaging Shared Resource, Chao Family
                      Cancer Center
                      University of California, IRVINE

Title:               New Technologies Towards Quantitatively Accurate Optical Molecular Imaging of Cancer

Date/Time:     Dec. 19, 2012 Wednesday @ 14:40

Place:             Sabanci University, SUNUM building, room G111

Abstract:

My main research area is molecular imaging, particularly developing novel multi-modality strategies for quantitatively accurate high-resolution in vivo optical imaging of thick tissues. For example, my team has developed a gantry-based combined X-ray CT and Optical Tomography system for animal imaging in fluorescence & bioluminescence modes. Another hybrid system that is being developed in our lab is a combined MRI-Diffuse Optical Tomography scanner for small animal and human breast cancer imaging in absorbance & fluorescence modes. Recently, we have developed two new techniques that are based on again multi-modality approach but different in nature that instead of working independently, both modalities work in synergy to offer images that cannot be obtained by either one alone. Photo-magnetic Tomography (PMT) heats the tissue using laser light and measure the temperature distribution deposited by light using Magnetic Resonance Imaging. Modeling photon migration and heat distribution in tissue, PMT aims to provide high resolution optical images of tissue. Meanwhile, Temperature Modulated Fluorescence Tomography (TM-FT) uses High Intensity Focused Ultrasound (HIFU) for localized heating of temperature-sensitive molecular probes termed "thermo-dots" to achieve higher resolution than conventional Fluorescence Tomography. In this talk, multi-modality imaging efforts in our lab will be summarized and the results of animal studies will be presented together with the efforts in translating these techniques for clinical breast imaging.

contact:             Inanc Adagideli, adagideli@sabanciuniv.edu