Prof. Gultekin Gulsen talk on optical molecular imaging
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  • Prof. Gultekin Gulsen talk on optical molecular imaging

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Physics Seminar

 Speaker:        Prof. Gultekin Gulsen,
                       Tu and Yuen Center for Functional Onco-Imaging,
                       Depts. of Radiology, BME, Physics, EECS
                       Director, Division of Optical Imaging, Dept. of Radiology
                       Director, In-vivo Functional Onco-Imaging
Shared  Resource, Chao Family  Cancer Center
                       University of California, IRVINE

 Title:               New Technologies Towards Quantitatively Accurate
 Optical Molecular Imaging of Cancer

 Date/Time:     Dec. 19, 2012 Wednesday @ 14:40

 Place:             Sabanci University, SUNUM building, room G111

 Abstract:

 My main research area is molecular imaging, particularly developing novel
 multi-modality strategies for quantitatively accurate high-resolution in
 vivo optical imaging of thick tissues. For example, my team has developed a
 gantry-based combined X-ray CT and Optical Tomography system for animal
 imaging in fluorescence & bioluminescence modes. Another hybrid system that
 is being developed in our lab is a combined MRI-Diffuse Optical Tomography
 scanner for small animal and human breast cancer imaging in absorbance &
 fluorescence modes. Recently, we have developed two new techniques that are
 based on again multi-modality approach but different in nature that instead
 of working independently, both modalities work in synergy to offer images
 that cannot be obtained by either one alone. Photo-magnetic Tomography (PMT)
 heats the tissue using laser light and measure the temperature distribution
 deposited by light using Magnetic Resonance Imaging. Modeling photon
 migration and heat distribution in tissue, PMT aims to provide high
 resolution optical images of tissue. Meanwhile, Temperature Modulated
 Fluorescence Tomography (TM-FT) uses High Intensity Focused Ultrasound
 (HIFU) for localized heating of temperature-sensitive molecular probes
 termed "thermo-dots" to achieve higher resolution than conventional
 Fluorescence Tomography. In this talk, multi-modality imaging efforts in our
 lab will be summarized and the results of animal studies will be presented
 together with the efforts in translating these techniques for clinical
 breast imaging.