SEMINAR: NOVEL METHOD FOR ICSI: ROTATIONALLY OSCILLATING DRILL19-10-2020
Speaker: Prof. Ali Fuat Ergenç, Istanbul Technical University, Control and Automation Dept
Title: A NOVEL METHOD FOR ICSI: ROTATIONALLY OSCILLATING DRILL
Date/Time: 21 October 2020 13:40 - 2:30 pm
Zoom: Meeting ID: 948 3324 9683 Passcode: 212758
Abstract: ICSI (intracytoplasmic sperm injection) procedure is an important assisted reproductive technology (ART), which is one of the commonly used cellular-injection processes. In essence, a drawn glass pipette is used to achieve the piercing and the injection. The process has evolved considerably since its inception. This procedure presently requires a very small mercury column inside a glass pipette which is impulsively forced via a piezo actuator. Despite the toxic mercury, the procedure is commonly utilized in many laboratories. Earlier investigations point out that the occurrence of considerable lateral tip oscillations of the injection pipette as the piezo-electric pulse train is introduced causes adverse effects on the success rate of the injection. The physics of the underlying cellular piercing process is quite complex and presently not fully understood, primarily due the inexistence of appropriate monitoring devices.
In this seminar the microinjection procedure is addressed. Development of an efficient and automated technology to prevent the lateral pipette movement during piercing. This technology is based on a rotationally oscillating micro-drill (Ros-Drill©). Ros-Drill© is a mercury-free and minimally invasive device which is designed and built including the peripheral control hardware and software. The experimental results exhibit high survival rate (> 70% of the injected oocytes) and fertilization rate (> 80% of the survived oocytes), and blastocyst formation rates (~ 50% of the survived oocytes).The blastocysts created by Ros-Drill© ICSI were transferred into the uteruses of pseudopregnant surrogate mothers and healthy pups were born and weaned.
Bio: Ali Fuat Ergenç, obtained his M.Sc. in 2001 and B.Sc. in 1999 in Control and Computer Engineering from Technical University of Istanbul, Turkey. He received his Ph.D. from Mechanical Engineering Department of University of Connecticut in 2007. He joined Department Control and Automation Eng. of Istanbul Technical University in 2008. He was a visiting researcher in MIT-HST in 2012. His research interests are biomechatronics, motion control and time delayed systems. Currently, he is the director of Motion and Power Control Lab. and Biosensor and Biorobotics Lab. in ITU. He is an affiliated member of EFSUN in Sabanci University.