DİNLE

Nanowarming for Regenerative Medicine15-10-2020

The “Applications of Engineering in Medicine and Biology” Seminar series


Abstract

Gold and iron oxide nanoparticles have unique and tunable properties that allow transduction of optical (light), or radiofrequency (RF) electromagnetic fields to affect heating of biomaterials at multiple scales. This talk will explore the underlying physics and relative advantages of each form of nanoparticle heating for therapeutic treatment of cancer or other disease by heating (i.e. magnetic hyperthermia or photothermal cancer therapy). In addition, this same heating helps improve regenerative medicine by “nanowarming” vitrified (i.e. cryopreserved) biomaterials back to a transplantable state through rapid and uniform warming that avoids crystallization and cracking. This nanoparticle warming addresses an important technology bottleneck for both large systems (i.e. tissues and organs) and smaller systems (i.e. embryos and oocytes). In summary, this talk demonstrates the growing opportunities for nanoparticle heating in biomedical applications.

 

Bio

John Bischof works in the area of thermal bioengineering with a focus on biopreservation, thermal therapy, and nanomedicine. His awards include the ASME Van Mow Medal and Fellowships in societies including Cryobiology, JSPS, ASME, and AIMBE. He has served as the President of the Society for Cryobiology and Chair of the Bioengineering Division of the ASME. Bischof obtained a B.S. in Bioengineering from U.C. Berkeley (UCB) in 1987, an M.S. from UCB and U.C. San Francisco in 1989, and a Ph.D. in Mechanical Engineering from UCB in 1992. After a Post-doctoral Fellowship at Harvard in the Center for Engineering in Medicine, he joined the University of Minnesota in 1993. John Bischof is now a Distinguished McKnight University Professor, Kuhrmeyer Chair in the Departments of Mechanical and Biomedical Engineering, and the Medtronic-Bakken Endowed Chair and Director of the Institute for Engineering in Medicine at the University of Minnesota. John Bischof is also Director of the NSF Engineering Research Center Advanced Technologies for Preservation of Biological Systems (ATP-Bio), which launched on September 1, 2020.

 

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