SEMINAR:Deep phenotyping sleep in Drosophila03-05-2021

Speaker: Mehmet Fatih Keleş

Title: Deep phenotyping sleep in Drosophila

Date/Time: 5 May 2021 / 17:40 - 18:30

Zoom: Meeting IDhttps://sabanciuniv.zoom.us/j/92551528471?pwd=M3huRE4yRnd2Z1Jqc2tteFlibENCQT09

Passcode: gradsem

Abstract: Although we spend a third of our lives sleeping, the function of this evolutionarily conserved behavior remains elusive. Studies in invertebrate model organisms have revealed novel genes regulating sleep. Majority of these identified genes are turned out to be also regulators of sleep in mammals.  However, sleep is considered to be unitary state in invertebrates, whereas mammalian sleep is composed of multiple states such as rapid eye movement sleep. Here, we hypothesize that fly sleep is also composed of multiple states, similar to mammals, marked by distinct behavioral programs. We use machine learning approaches combined with behavioral manipulation techniques to identify substages of sleep in flies. Our results suggest that flies have at least two distinct sleep stages, light sleep and deep sleep. Further studies will reveal if these behaviorally marked stages have underlying physiological basis and reminisce mammalian sleep substages.

Bio: Dr. Keleş finished his undergraduate studies at Bilkent University majoring in Molecular Biology and Genetics. He then joined Dr. Mark Frye’s group at UCLA to perform his graduate studies. His work focused on investigating the cellular and circuit mechanisms that govern visual object detection in Drosophila. He identified a novel circuit in the fly brain that can detect small moving objects. After completing his PhD, he joined Dr. Mark Wu’s group at Johns Hopkins University for his postdoctoral studies. There, he studies the molecular, cellular and circuit mechanisms of sleep in Drosophila.