Cavit Ağca | Faculty of Engineering and Natural Sciences

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Cavit Ağca Faculty Member

cavitagca@sabanciunivedu

(216) 483 9959

Areas of Interest

Retinal cell biology, gene therapy, gene regulation,
neuroprotection, regeneration, adeno-associated virus (AAV) and artificial
trans-activators/inhibitors (ATA/ATI).

Memberships

2011 SOG/SSO, Swiss Society of Ophthalmology 2011 ARVO, Association for Research in Vision and Ophthalmology 2012 Swiss Society of Neuroscience 2015 American Society of Gene and Cell Therapy

Publications

1. Agca, C*. and C. Grimm, A Simple Guide for Generating BAC Transgenic Animals for Retinal Research. Methods Mol Biol, 2020. 2092: p. 109-122.

*Corresponding author

2. Restelli, L. M., B. Oettinghaus, M. Halliday, C. Agca, M. Licci, L. Sironi, C. Savoia, J. Hench, M. Tolnay, A. Neutzner, A. Schmidt, A. Eckert, G. Mallucci, L. Scorrano and S. Frank,Neuronal Mitochondrial Dysfunction Activates the Integrated Stress Response to Induce Fibroblast Growth Factor 21. Cell Rep, 2018. 24(6): p. 1407-1414.

3. Mao, C. A*., C. Agca*, J. A. Mocko-Strand, J. Wang, E. Ullrich-Luter, P. Pan, S. W. Wang, M. I. Arnone, L. J. Frishman and W. H. Klein, Substituting mouse transcription factor Pou4f2 with a sea urchin orthologue restores retinal ganglion cell development. Proc Biol Sci, 2016. 283(1826): p. 20152978. Times cited: 2

*Both first authors played separate and major roles in this study. Each is equally worthy of being listed as first author.

4. Ebneter, A., C. Agca, C. Dysli and M. S. Zinkernagel. Investigation of retinal morphology alterations using spectral domain optical coherence tomography in a mouse model of retinal branch and central retinal vein occlusion. PLoS One, 2015. 10(3): p. e0119046.

5. Agca, C., K. Boldt, A. Gubler, I. Meneau, A. Corpet, M. Samardzija, M. Stucki, M. Ueffing and C. Grimm, Expression of leukemia inhibitory factor in Muller glia cells is regulated by a redox-dependent mRNA stability mechanism. BMC Biol, 2015. 13: p. 30.

6. Samardzija, M., C. Caprara, S. R. Heynen, S. Willcox DeParis, I. Meneau, G. Traber, C. Agca, J. von Lintig and C. Grimm., A mouse model for studying cone photoreceptor pathologies. Invest Ophthalmol Vis Sci, 2014. 55(8): p. 5304-13.

7. Agca, C. and C. Grimm, Leukemia inhibitory factor signaling in degenerating retinas. Adv Exp Med Biol, 2014. 801: p. 389-94.

8. Agca, C., A. Gubler, G. Traber, C. Beck, C. Imsand, D. Ail, C. Caprara and C. Grimm, p38 MAPK signaling acts upstream of LIF-dependent neuroprotection during photoreceptor degeneration. Cell Death Dis, 2013. 4: p. e785.

9. Agca, C., M. C. Elhajj, W. H. Klein and J. M. Venuti, Neurosensory and neuromuscular organization in tube feet of the sea urchin Strongylocentrotus purpuratus. J Comp Neurol, 2011. 519(17): p. 3566-79.

10. Agca, C., W.H. Klein, and J.M. Venuti, Respecification of ectoderm and altered Nodal expression in sea urchin embryos after cobalt and nickel treatment. Mech Dev, 2009. 126(5-6): p. 430-42.

11. Agca, C., W.H. Klein, and J.M. Venuti, Reduced O2 and elevated ROS in sea urchin embryos leads to defects in ectoderm differentiation. Dev Dyn, 2009. 238(7): p. 1777-87.

12. Sea Urchin Genome Sequencing consortium, Agca, C., et al., The genome of the sea urchin Strongylocentrotus purpuratus. Science, 2006. 314(5801): p. 941-52.

13.Burke, R. D., L. M. Angerer, M. R. Elphick, G. W. Humphrey, S. Yaguchi, T. Kiyama, S. Liang, X. Mu, C. Agca, W. H. Klein, B. P. Brandhorst, M. Rowe, K. Wilson, A. M. Churcher, J. S. Taylor, N. Chen, G. Murray, D. Wang, D. Mellott, R. Olinski, F. Hallbook and M. C. Thorndyke A genomic view of the sea urchin nervous system. Dev Biol, 2006. 300(1): p. 434-60.