Academic Seminar (Course)
FENS G035
19.03.2025 - All Day
BIO SEMINAR:Genome evolution of Fusarium oxysporum, a cross-kingdom...
Fusarium oxysporum is a cross-kingdom pathogenic fungus that can cause vascular wilt disease in many economically important plants and local or disseminated infections in humans. F. oxysporum can adapt to a wide range of hosts because of accessory chromosomes (ACs) which are enriched in host-specific genes and repeat content. We first compared the phenotypes and genomes of a plant pathogenic isolate F. oxysporum f. sp. lycopersici 4287 (Fol4287) and a human pathogenic isolate F. oxysporum MRL8996. Fol4287 and MRL8996 differ in both morphology and AC gene and repeat content. Then, we used experimental evolution to observe the quick adaptation of this fungus to different environments. Following whole genome resequencing of evolved populations, we detected many copy number variations, single nucleotide variations, insertions, deletions, and transposable element insertion variations (TIV). While transposons are the major cause of variation in both strains, the active transposons are different and encoded in their ACs. In addition, the Velvet complex, which is a major regulator of growth and mutated in multiple independent populations, has an important role in the adaptation of F. oxysporum.