| Faculty of Engineering and Natural Sciences

Emrah Eroğlu Faculty of Engineering and Natural Sciences Network Faculty Member (216) 483 9597 emraheroglusabanciunivedu

Jobs

Network Faculty Member

Education

2019- Principle Investigator (Sabanci University)

2017-2019 Postdoctoral Fellow (Harvard Medical School)

2016 -2017 Postdoctoral Fellow (MedUni Graz)

2015 -2016 PhD Student Molecular Medicine (Molecular Medicine Program, MedUni Graz)

2013-present Medicine (Meduni Graz)

2012 -2015 Master’s degree in Biotechnology and Bioanalytics (Vienna University of Technology)

2012 -2012 Exam for nationally certified pharmaceutical representative (Ministry of Health, Austria).

2008 -2012 Bachelor’s degree in Biology and Molecular biology (Vienna University)

2007 -2008 University entrance exam (Vienna University)

Areas of Interest

Design and development of genetically encoded biosensors, High-resolution live-cell imaging, Nitric oxide biochemistry, Chemogenetic approaches, Cell physiology

Memberships

AHA American Heart Association, SFRR-E Society for Free Radical Research Europe, Austrian Association of Molecular Life Sciences and Biotechnology

Barakat, Sarah and Çimen, Şeyma and Miri, Seyed Mohammad and Vatandaşlar, Emre and Yelkenci, Hayriye Ecem and San Martín, Alejandro and Beker, Mustafa Çağlar and Kök, Kıvanç and Öztürk, Gürkan and Eroğlu, Emrah (2024) "Bioenergetic shift and proteomic signature induced by lentiviral-transduction of GFP-based biosensors", Redox Biology, Vol.78 (SCI)

Altun, Hamza Yusuf and Seçilmiş, Melike and Yang, Fan and Akgül Çağlar, Tüba and Vatandaşlar, Emre and Toy, Muhammed Fatih and Vilain, Sven and Mann, Giovanni E. and Öztürk, Gürkan and Eroğlu, Emrah (2024) "Visualizing hydrogen peroxide and nitric oxide dynamics in endothelial cells using multispectral imaging under controlled oxygen conditions", Free Radical Biology and Medicine, Vol.221, 89-97 (SCI)

Groschup, Bernhard and Calandra, Gian Marco and Raitmayr, Constanze and Shrouder, Joshua and Llovera, Gemma and Ghaffari Zaki, Asal and Burgstaller, Sandra and Bischof, Helmut and Eroğlu, Emrah and Liesz, Arthur and Malli, Roland and Filser, Severin and Plesnila, Nikolaus (2024) "Probing intracellular potassium dynamics in neurons with the genetically encoded sensor lc-LysM GEPII 1.0 in vitro and in vivo", Scientific Reports, Vol.14, No.1 (SCI)

Ghaffari Zaki, Asal and Yiğit, Esra N. and Aydın, Mehmet Ş and Vatandaslar, Emre and Öztürk, Gürkan and Eroğlu, Emrah (2024) "Genetically encoded biosensors unveil neuronal injury dynamics via multichromatic ATP and calcium imaging", ACS Sensors, Vol.9, No.3, 1261-1271 (SCI)

Ghaffari Zaki, Asal and Miri, Seyed Mohammad and Çimen, Şeyma and Akgül Çağlar, Tüba and Yiğit, Esra N. and Aydın, Mehmet Ş and Öztürk, Gürkan and Eroğlu, Emrah (2023) "Development of a chemogenetic approach to manipulate intracellular pH", Journal of the American Chemical Society, Vol.145, No.22, 11899-11902 (SCI)

Sevimli, Gülşah and Alston, Amy E. and Funk, Felix and Flühmann, Beat and Malli, Roland and Graier, Wolfgang F. and Eroğlu, Emrah (2022) "Probing subcellular iron availability with genetically encoded nitric oxide biosensors", Biosensors, Vol.12, No.10 (SCI)

Pandey, Arvind K. and Waldeck-Weiermair, Markus and Wells, Quinn S. and Xiao, Wusheng and Yadav, Shambhu and Eroğlu, Emrah and Michel, Thomas and Loscalzo, Joseph (2022) "Expression of CD70 modulates nitric oxide and redox status in endothelial cells", Arteriosclerosis, Thrombosis, and Vascular Biology, Vol.42, No.9, 1169-1185 (SCI)

Sevimli, Gülşah and Smith, Matthew J. and Akgül Çağlar, Tüba and Bilir, Şükriye and Seçilmiş, Melike and Altun, Hamza Yusuf and Yigit, Esra N. and Yang, Fan and Keeley, Thomas P. and Malli, Roland and Öztürk, Gürkan and Mann, Giovanni E. and Eroğlu, Emrah (2022) "Nitric oxide biosensor uncovers diminished ferrous iron-dependency of cultured cells adapted to physiological oxygen levels", Redox Biology, Vol.53 (SCI)

Ghaffari Zaki, Asal and Erdoǧan, Yusuf C. and Akgül Çağlar, Tüba and Eroğlu, Emrah (2022) "Chemogenetic approaches to dissect the role of H2O2 in redox-dependent pathways using genetically encoded biosensors", Biochemical Society Transactions, Vol.50, No.1, 335-345 (SCI)

Steinhorn, Benjamin and Eroğlu, Emrah and Michel, Thomas (2022) "Chemogenetic approaches to probe redox pathways: implications for cardiovascular pharmacology and toxicology", Annual Review of Pharmacology and Toxicology, Vol.62, 551-571 (SCI)

Erdoğan, Yusuf Ceyhun and Altun, Hamza Yusuf and Seçilmiş, Melike and Ata, Büşra Nur and Sevimli, Gülşah and Çokluk, Zeynep and Ghaffari Zaki, Asal and Sezen, Serap and Akgul Caglar, Tuba and Sevgen, İlker and Steinhorn, Benjamin and Ai, Huiwang and Öztürk, Gürkan and Belousov, Vsevelod V. and Michel, Thomas and Eroğlu, Emrah (2021) "Complexities of the chemogenetic toolkit: differential mDAAO activation by D-amino substrates and subcellular targeting", Free Radical Biology and Medicine, Vol.177, 132-142 (SCI)

Seçilmiş, Melike and Altun, Hamza Yusuf and Pilic, Johannes and Erdoğan, Yusuf Ceyhun and Çokluk, Zeynep and Ata, Büşra Nur and Sevimli, Gülşah and Ghaffari Zaki, Asal and Yigit, Esra Nur and Öztürk, Gürkan and Malli, Roland and Eroğlu, Emrah (2021) "A co-culture-based multiparametric imaging technique to dissect local h2o2 signals with targeted hyper7", Biosensors, Vol.11, No.9 (SCI)

Collins, John A. and Kapustina, Maryna and Bolduc, Jesalyn A. and Pike, James F.W. and Diekman, Brian O. and Mix, Kimberlee and Chubinskaya, Susan and Eroğlu, Emrah and Michel, Thomas and Poole, Leslie B. and Furdui, Cristina M. and Loeser, Richard F. (2021) "Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes", Free Radical Biology and Medicine, Vol.166, 90-103 (SCI)

Saeedi Saravi, Seyed Soheil and Eroğlu, Emrah and Waldeck-Weiermair, Markus and Sorrentino, Andrea and Steinhorn, Benjamin and Belousov, Vselovod and Michel, Thomas (2020) "Differential endothelial signaling responses elicited by chemogenetic H2O2 synthesis", Redox Biology, Vol.36 (SCI)

Eroğlu, Emrah and Michel, Thomas and Graier, Wolfgang F. and Malli, Roland (2020) "Yes (again) to local NO", Nature Chemical Biology, Vol.16, No.6, 606-607 (SCI)

Eroğlu, Emrah and Saeedi Saravi, Seyed Soheil and Sorrentino, Andrea and Steinhorn, Benjamin and Michel, Thomas (2019) "Discordance between eNOS phosphorylation and activation revealed by multispectral imaging and chemogenetic methods", Proceedings of the National Academy of Sciences of the United States of America, Vol.116, No.40, 20210-20217 (SCI)

Eroglu E, Michel T, Graier W, Malli R. Yes (again) to local NO. Nature Chemical Biology volume 16, pages 606–607(2020) Seyed Soheil Saeedi Saravi*, Emrah Eroglu*, Markus Waldeck-Weiermair, Andrea Sorrentino, Benjamin Steinhorn, Vselovod Belousov, Thomas Michel (2020) Differential endothelial signaling responses elicited by chemogenetic H2O2 synthesis, Redox Biology, https://doi.org/10.1016/j.redox.2020.101605. Valeriy V.Pak, DariaEzeriņa, Olga G.Lyublinskaya, BrandánPedre, Pyotr A.Tyurin-Kuzmin, Natalie M.Mishina, MarionThauvin, DavidYoung, KhadijaWahni, Santiago AgustínMartínez Gache, Alexandra D.Demidovich, Yulia G.Ermakova, Yulia D.Maslova, Arina G.Shokhina, EmrahEroglu, Dmitry S.Bilan, IvanBogeski, ThomasMichel, SophieVriz, JorisMessens, Vsevolod V.Belousov (2020) Cell Metabolism Volume 31, Issue 3, 3 March 2020, Pages 642-653.e6 Ultrasensitive Genetically Encoded Indicator for Hydrogen Peroxide Identifies Roles for the Oxidant in Cell Migration and Mitochondrial Function

Markus Waldeck-Weiermair, Benjamin Gottschalk, Corina T Madreiter Sokolowski, Jeta Ramadani-Muja, Gabriella Ziomek, Christiane Klec, Sandra Burgstaller, Helmut Bischof, Maria R Depaoli, Emrah Eroglu, Roland Malli, Wolfgang F Graier, Front. Cell. Neurosci., 04 October 2019 | – Development and application of sub-mitochondrial targeted Ca2+ biosensors

Emrah Eroglu, Seyed Soheil Saeedi Saravi, Andrea Sorrentino, Benjamin Steinhorn, and Thomas Michel. Discordance between eNOS phosphorylation and activation revealed by multispectral imaging and chemogenetic approaches. PNAS September 16, 2019 https://doi.org/10.1073/pnas.1910942116

Gottschalk B, Klec C, Leitinger G, Bernhart E, Rost R, Bischof H, Madreiter-Sokolowski CT, Radulović S, Eroglu E, Sattler W, Waldeck-Weiermair M, Malli R, Graier WF. MICU1 controls cristae junction and spatially anchors mitochondrial Ca(2+) uniporter complex. Nat Commun. 2019 Aug 19;10(1):3732. doi: 10.1038/s41467-019-11692-x. PubMed PMID: 31427612; PubMed Central PMCID: PMC6700202.

Sorrentino A, Steinhorn B, Troncone L, Saravi SSS, Badole S, Eroglu E, Kijewski MF, Divakaran S, Di Carli M, Michel T. Reversal of heart failure in a chemogenetic model of persistent cardiac redox stress. Am J Physiol Heart Circ Physiol. 2019 Sep 1;317(3):H617-H626. doi: 10.1152/ajpheart.00177.2019. Epub 2019 Jul 12. PubMed PMID: 31298558.

Depaoli MR, Bischof H, Eroglu E, Burgstaller S, Ramadani-Muja J, Rauter T, Schinagl M, Waldeck-Weiermair M, Hay JC, Graier WF, Malli R. Live cell imaging of signaling and metabolic activities. Pharmacol Ther. 2019 Jun 7. pii: S0163-7258(19)30110-X. doi: 10.1016/j.pharmthera.2019.06.003. [Epub ahead of print] Review. PubMed PMID: 31176696.

Burgstaller S, Bischof H, Gensch T, Stryeck S, Gottschalk B, Ramadani-Muja J, Eroglu E, Rost R, Balfanz S, Baumann A, Waldeck-Weiermair M, Hay JC, Madl T, Graier WF, Malli R. pH-Lemon, a Fluorescent Protein-Based pH Reporter for Acidic Compartments. ACS Sens. 2019 Apr 26;4(4):883-891. doi: 10.1021/acssensors.8b01599. Epub 2019 Mar 30. PubMed PMID: 30864782; PubMed Central PMCID: PMC6488996.

Depaoli MR, Karsten F, Madreiter-Sokolowski CT, Klec C, Gottschalk B, Bischof H, Eroglu E, Waldeck-Weiermair M, Simmen T, Graier WF, Malli R. Real-Time Imaging of Mitochondrial ATP Dynamics Reveals the Metabolic Setting of Single Cells. Cell Rep. 2018 Oct 9;25(2):501-512.e3. doi: 10.1016/j.celrep.2018.09.027. PubMed PMID: 30304688; PubMed Central PMCID: PMC6456002.

Deak AT, Gottschalk B, Eroglu E, Rost R, Waldeck-Weiermair M, Graier WF, Malli R. High-Resolution Imaging of STIM/Orai Subcellular Localization Using Array Confocal Laser Scanning Microscopy. Methods Mol Biol. 2018;1843:175-187. doi: 10.1007/978-1-4939-8704-7_15. PubMed PMID: 30203287.

Eroglu E, Bischof H, Charoensin S, Waldeck-Weiermaier M, Graier WF, Malli R. Real-Time Imaging of Nitric Oxide Signals in Individual Cells Using geNOps. Methods Mol Biol. 2018;1747:23-34. doi: 10.1007/978-1-4939-7695-9_3. PubMed PMID: 29600448.

Eroglu E, Charoensin S, Bischof H, Ramadani J, Gottschalk B, Depaoli MR, Waldeck-Weiermair M, Graier WF, Malli R. Genetic biosensors for imaging nitric oxide in single cells. Free Radic Biol Med. 2018 Nov 20;128:50-58. doi: 10.1016/j.freeradbiomed.2018.01.027. Epub 2018 Feb 2. Review. PubMed PMID: 29398285; PubMed Central PMCID: PMC6173299.

Opelt M, Wölkart G, Eroglu E, Waldeck-Weiermair M, Malli R, Graier WF, Kollau A, Fassett JT, Schrammel A, Mayer B, Gorren ACF. Sustained Formation of Nitroglycerin-Derived Nitric Oxide by Aldehyde Dehydrogenase-2 in Vascular Smooth Muscle without Added Reductants: Implications for the Development of Nitrate Tolerance. Mol Pharmacol. 2018 Apr;93(4):335-343. doi: 10.1124/mol.117.110783. Epub 2018 Jan 22. PubMed PMID: 29358221; PubMed Central PMCID: PMC5933520.

Bischof H, Rehberg M, Stryeck S, Artinger K, Eroglu E, Waldeck-Weiermair M, Gottschalk B, Rost R, Deak AT, Niedrist T, Vujic N, Lindermuth H, Prassl R, Pelzmann B, Groschner K, Kratky D, Eller K, Rosenkranz AR, Madl T, Plesnila N, Graier WF, Malli R. Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo. Nat Commun. 2017 Nov 10;8(1):1422. doi: 10.1038/s41467-017-01615-z. PubMed PMID: 29127288; PubMed Central PMCID: PMC5681659.

Eroglu E, Hallström S, Bischof H, Opelt M, Schmidt K, Mayer B, Waldeck-Weiermair M, Graier WF, Malli R. Real-time visualization of distinct nitric oxide generation of nitric oxide synthase isoforms in single cells. Nitric Oxide. 2017 Nov 1;70:59-67. doi: 10.1016/j.niox.2017.09.001. Epub 2017 Sep 4. PubMed PMID: 28882669; PubMed Central PMCID: PMC6002809.

Eroglu E, Rost R, Bischof H, Blass S, Schreilechner A, Gottschalk B, Depaoli MR, Klec C, Charoensin S, Madreiter-Sokolowski CT, Ramadani J, Waldeck-Weiermair M, Graier WF, Malli R. Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells. J Vis Exp. 2017 Mar 16;(121). doi: 10.3791/55486. PubMed PMID: 28362417; PubMed Central PMCID: PMC5408997.

Charoensin S, Eroglu E, Opelt M, Bischof H, Madreiter-Sokolowski CT, Kirsch A, Depaoli MR, Frank S, Schrammel A, Mayer B, Waldeck-Weiermair M, Graier WF, Malli R. Intact mitochondrial Ca(2+) uniport is essential for agonist-induced activation of endothelial nitric oxide synthase (eNOS). Free Radic Biol Med. 2017 Jan;102:248-259. doi: 10.1016/j.freeradbiomed.2016.11.049. Epub 2016 Dec 5. PubMed PMID: 27923677; PubMed Central PMCID: PMC5381715.

Opelt M, Eroglu E, Waldeck-Weiermair M, Russwurm M, Koesling D, Malli R, Graier WF, Fassett JT, Schrammel A, Mayer B. Formation of Nitric Oxide by Aldehyde Dehydrogenase-2 Is Necessary and Sufficient for Vascular Bioactivation of Nitroglycerin. J Biol Chem. 2016 Nov 11;291(46):24076-24084. Epub 2016 Sep 27. PubMed PMID: 27679490; PubMed Central PMCID: PMC5104933.

Madreiter-Sokolowski CT, Gottschalk B, Parichatikanond W, Eroglu E, Klec C, Waldeck-Weiermair M, Malli R, Graier WF. Resveratrol Specifically Kills Cancer Cells by a Devastating Increase in the Ca2+ Coupling Between the Greatly Tethered Endoplasmic Reticulum and Mitochondria. Cell Physiol Biochem. 2016;39(4):1404-20. doi: 10.1159/000447844. Epub 2016 Sep 9. PubMed PMID: 27606689; PubMed Central PMCID: PMC5382978.

Madreiter-Sokolowski CT, Klec C, Parichatikanond W, Stryeck S, Gottschalk B, Pulido S, Rost R, Eroglu E, Hofmann NA, Bondarenko AI, Madl T, Waldeck-Weiermair M, Malli R, Graier WF. PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca(2+) uptake in immortalized cells. Nat Commun. 2016 Sep 19;7:12897. doi: 10.1038/ncomms12897. PubMed PMID: 27642082; PubMed Central PMCID: PMC5031806.

Malli R, Eroglu E, Waldeck-Weiermair M, Graier WF. Filling a GAP-An Optimized Probe for ER Ca(2+) Imaging In Vivo. Cell Chem Biol. 2016 Jun 23;23(6):641-3. doi: 10.1016/j.chembiol.2016.06.003. PubMed PMID: 27341431.

Eroglu E, Gottschalk B, Charoensin S, Blass S, Bischof H, Rost R, Madreiter-Sokolowski CT, Pelzmann B, Bernhart E, Sattler W, Hallström S, Malinski T, Waldeck-Weiermair M, Graier WF, Malli R. Development of novel FP-based probes for live-cell imaging of nitric oxide dynamics. Nat Commun. 2016 Feb 4;7:10623. doi: 10.1038/ncomms10623. PubMed PMID: 26842907; PubMed Central PMCID: PMC4743004.

Waldeck-Weiermair M, Bischof H, Blass S, Deak AT, Klec C, Graier T, Roller C, Rost R, Eroglu E, Gottschalk B, Hofmann NA, Graier WF, Malli R. Generation of Red-Shifted Cameleons for Imaging Ca²⁺ Dynamics of the Endoplasmic Reticulum. Sensors (Basel). 2015 Jun 4;15(6):13052-68. doi: 10.3390/s150613052. PubMed PMID: 26053751; PubMed Central PMCID: PMC4507692.