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Alex LyakhovichFaculty of Engineering and Natural SciencesFaculty Member(216) 483 9506alexlyakhovichsabanciunivedu

Faculty Member

Areas of Interest

Cancer biology, Mitochondrial dysfunction, Aging & personalized medicine, Rare diseases. Current research projects: (i) antibiotics targeting mitochondrial functions; (ii) cancer stem cells, cancer resistance and the role of OXPHOS; (iii) exosomes and horizontal mitochondrial transfer; (iv) organ-based biological clock.


American Association for Cancer Research (AACR) FEBS (British Biochemical Society)

Publications Prior to SU

*corresponding,  D1 – top 10%, Q1 – top 25%.


Etna Abad, Sara Samino, Giovanni Pagano, Dmitry Graifer, David Potesil, Zbynek Zdrahal, Oscar Yanes, and Lyakhovich A*, Increased de novo purine biosynthesis and purinosome formation in Fanconi anemia cells as one of the factors of cancer susceptibility. Cancer Letters, 2020;503:185-196., D1 IF: 8.68

Pavlova JA, Khairullina ZZ, Tereshchenkov AG, Nazarov PA, Lukianov DA, Volynkina IA, Skvortsov DA, Makarov GI, Abad E, Murayama SY, Kajiwara S, Paleskava A, Konevega AL, Antonenko YN, Lyakhovich A, Osterman IA, Bogdanov AA, Sumbatyan NV. Triphenilphosphonium Analogs of Chloramphenicol as Dual-Acting Antimicrobial and Antiproliferating Agents. Antibiotics (Basel). 2021;10(5):489. doi: 10.3390/antibiotics10050489. Q1 IF: 4.36

Klionsky D ….. Lyakhovich A. et al Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy. Autophagy, 2020;17(1):1-382. D1 IF:16.02

Giovanni Pagano, Luca Tiano, Federico V. Pallardó, Alex Lyakhovich, Sudit S. Mukhopadhyay, Paolo Di Bartolomeo, Adriana Zatterale, Marco Trifuoggi Re-definition and Supporting Evidence toward Fanconi Anemia as a Mitochondrial Disease: Prospects for New Design in Clinical Management, Redox Biology, 2021;40:101860. doi: 10.1016/j.redox.2021.101860.  D1 IF:11.8

Abad E, Civit L, Potesil D, Zdrahal Z, Lyakhovich A*. Enhanced DNA damage response through RAD50 in triple negative breast cancer resistant and cancer stem-like cells contributes to chemoresistance. The FEBS Journal, 2020, 288(7):2184-2202. doi: 10.1111/febs.15588. PMID: 33090711, Q1 IF:5.54

Giovanni Pagano, Federico V. Pallardó, Alex Lyakhovich, Luca Tiano, Maria Rosa Fittipaldi, Maria Toscanesi, Marco Trifuoggi. Aging-related Disorders and Mitochondrial Dysfunction: A Critical Review for Prospect Mitoprotective Strategies Based on Mitochondrial Nutrient Mixtures. Int. J. Mol. Sci. 2020, 21(19):7060. doi: 10.3390/ijms21197060. PMID: 32992778Q1, IF:5.92

Abad E, Graifer D, Lyakhovich A* DNA damage response and resistance of cancer stem cells. Cancer Letters 2020; 503:185-196. doi: 10.1016/j.canlet.2020.12.010. PMID: 33316348 D1 IF: 8.68

Pallardó FV, Pagano G, Rodríguez LR, Gonzalez-Cabo P, Lyakhovich A, Trifuoggi M. Transl Res. 2020; 229:135-141. doi: 10.1016/j.trsl.2020.08.009. PMID: 32841735  D1 IF:5.3

Etna Abad, Sara Samino, Oscar Yanes, David Potěšil, Zbyněk Zdráhal, Alex Lyakhovich* Activation of glycogenolysis and glycolysis in breast cancer stem cell models. BBA - Molecular Bases of Disease, 2020;1866(10):165886. doi: 10.1016/j.bbadis.2020.165886. PMID: 32592934165886 Q1 IF:5.19

Pagano G, Pallardò FV, Porto B, Fittipaldi MR, Lyakhovich A, Trifuoggi M, Mitoprotective clinical strategies in type 2 diabetes and Fanconi anemia patients: Suggestions for clinical management of mitochondrial dysfunction. Antioxidants, 2020 18;9(1). pii: E82. doi: 10.3390/antiox9010082 Q1 IF:5.95

Giovanni Pagano, Carla Manfredi, Federico V. Pallardó, Alex Lyakhovich, Luca Tiano, Marco Trifuoggi Potential Roles of Mitochondrial Cofactors in Adjuvant Mitigation the Proinflammatory Conditions in Acute Infections, as in the Case of COVID-19 Pneumonia. Inflammation Research 2020; 21:1-12. doi: 10.1007/s00011-020-01423-0, PMID: 33346851 Q1 IF:6.92

Abad E, García-Mayea Y, Mir C, Sebastian D, Zorzano A, Potesil D., Zdrahal Z., Lyakhovich A*, Lleonart M*. Common metabolic pathways implicated in resistance to chemotherapy point to a key mitochondrial role in breast cancer. Mol Cell Proteomics. 2019; 18(2):231-244. doi: 10.1074/mcp.RA118.001102. PMID: 30373788 (journal coverD1 IF:5.91

Lorente J, Velandia C, Leal JA, Garcia-Mayea Y, Lyakhovich A, et al. The interplay between autophagy and tumorigenesis: exploiting autophagy as a means of anticancer therapy. Biol Rev Camb Philos Soc. 2018;93(1):152-165. PubMed PMID: 28464404. D1 IF:12.82

Feliciano A, Garcia-Mayea Y, Jubierre L, Mir C, Hummel M, Lyakhovich A et al. miR-99a reveals two novel oncogenic proteins E2F2 and EMR2 and represses stemness in lung cancer. Cell Death Dis. 2017;8(10):e3141. PubMed PMID: 29072692; Q1 IF:8.47

Lleonart ME, Grodzicki R, Graifer DM, Lyakhovich A*. Mitochondrial dysfunction and potential anticancer therapy. Med Res Rev. 2017;37(6):1275-1298. PubMed PMID: 28682452. D1 IF:12.94

Lleonart ME, Abad E, Graifer D, Lyakhovich A*. Reactive Oxygen Species-Mediated Autophagy Defines the Fate of Cancer Stem Cells. Antioxid Redox Signal. 2017; PMID: 28683561. D1 IF:7.04

Graterol D, Mir C, Garcia-Vaquero C, Braña I, Pardo AN, Lyakhovich A et al. Absence of Relationship between Mitochondrial DNA Haplogroups and Cisplatin-Induced Hearing Loss. Int J Otolaryngol. 2017;2017:5185268. PubMed PMID: 28757873; PubMed Central PMCID: PMC5512046. Q3 IF:1.3

Esner M, Graifer D, Lleonart ME, Lyakhovich A*. Targeting cancer cells through antibiotics-induced mitochondrial dysfunction requires autophagy inhibition. Cancer Lett. 2017;384:60-69. PubMed PMID: 27693455. D1 IF:8.68

Shyamsunder P, Esner M, Barvalia M, Wu YJ, Loja T, Krejci L, Lyakhovich A*. Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission. Oncotarget. 2016;7(36):58065-58074. PubMed PMID: 27517150; PubMed Central PMCID: PMC5295412.Q1  IF:5.02

Lyakhovich A*, Graifer D, Stefanovie B, Krejci L. Mitochondrial dysfunction in DDR-related cancer predisposition syndromes. Biochim Biophys Acta. Rev. Cancer 2016;1865(2):184-9. PubMed PMID: 26926806. D1 IF:10.68

Lyakhovich A*, Lleonart ME. Bypassing Mechanisms of Mitochondria-Mediated Cancer Stem Cells Resistance to Chemo- and Radiotherapy. Oxid Med Cell Longev. 2016;2016:1716341. PubMed PMID: 26697128; PubMed Central PMCID: PMC4677234. Q1 IF:6.54

Epanchintsev A, Shyamsunder P, Verma RS, Lyakhovich A*. IL-6, IL-8, MMP-2, MMP-9 are overexpressed in Fanconi anemia cells through a NF-κB/TNF-α dependent mechanism. Mol Carcinog. 2015;54(12):1686-99. PubMed PMID: 25358651. Q1 IF:4.78

Shyamsunder P, Verma RS, Lyakhovich A*. ROMO1 regulates RedOx states and serves as an inducer of NF-κB-driven EMT factors in Fanconi anemia. Cancer Lett. 2015;361(1):33-8. PubMed PMID: 25687884. D1 IF:8.68

Lyakhovich A*, Graifer D. Mitochondria-Mediated Oxidative Stress: Old Target for New Drugs. Curr Med Chem. 2015;22(26):3040-53. PubMed PMID: 26219394. Q1 IF:4.18

Pagano G, Shyamsunder P, Verma RS, Lyakhovich A*. Damaged mitochondria in Fanconi anemia - an isolated event or a general phenomenon?. Oncoscience. 2014;1(4):287-95. PubMed PMID: 25594021; PubMed Central PMCID: PMC4278298. IF:3.1

Khare V, Lang M, Dammann K, Campregher C, Lyakhovich A, et al. Modulation of N-glycosylation by mesalamine facilitates membranous E-cadherin expression in colon epithelial cells. Biochem Pharmacol. 2014;87(2):312-20. PubMed PMID: 24184502; PubMed Central PMCID: PMC3905164. Q1 IF:5.86

Kumari U, Ya Jun W, Huat Bay B, Lyakhovich A*. Evidence of mitochondrial dysfunction and impaired ROS detoxifying machinery in Fanconi anemia cells. Oncogene. 2014;33(2):165-72. PubMed PMID: 23318445. D1 IF: 9.87

Lyakhovich A*. Damaged mitochondria and overproduction of ROS in Fanconi anemia cells. Rare Dis. 2013;1:e24048. PubMed PMID: 25002988; PubMed Central PMCID: PMC3915560.

Khare V, Lyakhovich A, Dammann K, Lang M, Borgmann M, et al. Mesalamine modulates intercellular adhesion through inhibition of p-21 activated kinase-1. Biochem Pharmacol. 2013;85(2):234-44. PubMed PMID: 23146664; PubMed Central PMCID: PMC3557386. Q1, IF:5.86

Lyakhovich A, Michlmayr A, Bakulina A, Gerner C, Oehler R, et al. Interaction of mesalasine (5-ASA) with translational initiation factors eIF4 partially explains 5-ASA anti-inflammatory and anti-neoplastic activities. Med Chem. 2011;7(2):92-8. PubMed PMID: 21222616. Q2, IF:2.75

Lyakhovich A, Ramirez MJ, Castellanos A, Castella M, Simons AM, et al. Fanconi anemia protein FANCD2 inhibits TRF1 polyADP-ribosylation through tankyrase1-dependent manner. Genome Integr. 2011;2(1):4. PubMed PMID: 21314979; PubMed Central PMCID: PMC3048478. IF:1.39

Campregher C, Luciani MG, Biesenbach P, Evstatiev R, Lyakhovich A, et al. The position of the amino group on the benzene ring is critical for mesalamine's improvement of replication fidelity. Inflamm Bowel Dis. 2010;16(4):576-82. PubMed PMID: 19821510. Q1, IF:4.53

Lyakhovich A, Gasche C. Systematic review: molecular chemoprevention of colorectal malignancy by mesalazine. Aliment Pharmacol Ther. 2010;31(2):202-9. PubMed PMID: 19891667. D1, IF:8.17

Lyakhovich A*, Surrallés J. Constitutive activation of caspase-3 and Poly ADP ribose polymerase cleavage in fanconi anemia cells. Mol Cancer Res. 2010;8:46-56. PubMed PMID: 20068062. Q1, IF:6.26

Lyakhovich A*, Bech-Serra JJ, Canals F, Surralles J. Quick two-dimensional differential in gel electrophoresis-based method to determine length and secondary structures of telomeric DNA. Anal Biochem. 2009;384(2):356-8. PubMed PMID: 18938127.Q2, IF:3.36

Lyakhovich A, Surralles J. FANCD2 depletion sensitizes cancer cells repopulation ability in vitro. Cancer Lett. 2007;256(2):186-95. PubMed PMID: 17643815. D1 IF: 8.68

Lyakhovich A*, Canals F, Nosov M, Surralles J. A DIGE-based approach to study interacting proteins. J Biochem Biophys Methods. 2007;70(4):693-5. PubMed PMID: 17433449. Q3, IF3.54

Lyakhovich A, Surrallés J. New roads to FA/BRCA pathway: H2AX. Cell Cycle. 2007;6(9):1019-23. PubMed PMID: 17471025. Q1, IF:4.53

Bogliolo M, Lyakhovich A, Callén E, Castellà M, Cappelli E, et al. Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability. EMBO J. 2007;26(5):1340-51. PubMed PMID: 17304220; equal co-authorship D1, IF:11.60

Lyakhovich A, Surralles J. Disruption of the Fanconi anemia/BRCA pathway in sporadic cancer. Cancer Lett. 2006;232(1):99-106. PubMed PMID: 16246487. D1 IF: 8.68

Lyakhovich A, Shekhar MP. RAD6B overexpression confers chemoresistance: RAD6 expression during cell cycle and its redistribution to chromatin during DNA damage-induced response. Oncogene. 2004;23(17):3097-106. PubMed PMID: 14981545. D1, IF:9.87

Lyakhovich A, Shekhar MP. Supramolecular complex formation between Rad6 and proteins of the p53 pathway during DNA damage-induced response. Mol Cell Biol. 2003;23(7):2463-75. PubMed PMID: 12640129; PubMed Central PMCID: PMC150718. Q1 IF:4.27 (8.9 at that time)

 Shekhar MP, Lyakhovich A, Visscher DW, Heng H, Kondrat N. Rad6 overexpression induces multinucleation, centrosome amplification, abnormal mitosis, aneuploidy, and transformation. Cancer Res. 2002;62(7):2115-24. PubMed PMID: 11929833. D1 IF:12.70

Aksenov NL, Liakhovich AV, Mikhel'son VM, Spivak IV, Tuohimaa P, et al. [Identification of elements responsible for regulation of keratinocyte growth factor gene by steroid hormones and 1,25-dihydroxyvitamin D3]. Tsitologiia. 2001;43(11):1038-45. PubMed PMID: 11840779. IF0.79

Tuohimaa P, Lyakhovich A, Aksenov N, Pennanen P, Syvälä H, et al. Vitamin D and prostate cancer. J Steroid Biochem Mol Biol. 2001;76(1-5):125-34. PubMed PMID: 11384870. Q2, IF:3.78

Lyakhovich A*, Aksenov N, Pennanen P, Miettinen S, Ahonen MH, et al. Vitamin D induced up-regulation of keratinocyte growth factor (FGF-7/KGF) in MCF-7 human breast cancer cells. Biochem Biophys Res Commun. 2000;273(2):675-80. PubMed PMID: 10873663. Q2, IF:3.57

Book chapters

Meigs TE, Lyakhovich A. Encyclopedia of Signaling Molecules. 2 ed. Choi S, editor. New York, NY: ISBN: 978-1-4939-6801-5: Springer-Verlag New York; 2017. Chapter, G Protein Alfa 12 and 13; p.7-33. 539p

Shyamsunder P, Verma RS, Mukhopadhyay SS, Lyakhovich A*. Fanconi Anemia and Oxidative Stress: Mechanistic Background and Clinical Prospects. Ed. Pagano G, New York: Nova Science Pub Inc ; 2015. Chapter 4, Involvement of Mitochondria in the Pathology of Fanconi Anemia ISBN: 971634638326

Lyakhovich A, Castella M, Surralles J. Genomic Instability and Cancer. Hande PM, Hande VK, editors. Singapore ISBN 978-81-308-0405-7: Research Signpost Publisher; 2009. Fanconi Anaemia, chromosome instability and cancer

Lyakhovich A, Surralles J. Frontiers in Breast Cancer Research. NY 2007 ISBN: 1-60021-671-4 : Nova Science Publishers, Hauppauge; 2007. How Fanconi Anemia and Breast Cancer are connected.