| Faculty of Engineering and Natural Sciences

Umut Şahin Faculty of Engineering and Natural Sciences Faculty Member (216) 483 9538 umutsahinsabanciunivedu

Personal Web

http://myweb.sabanciuniv.edu/sahin/

Jobs

Faculty Member

Areas of Interest

Cell biology & Biochemistry; Protein Post-translational Modifications; Protein Stability and Degradation; Ubiquitin-Proteasome System; Ubiquitin-like modifications; SUMOylation; Targeted Therapies & Precision Medicine; Neurodegeneration; Amyotrophic Lateral Sclerosis (ALS); Cancer Mechanisms.

Çakar A, Pekbilir E, Ceylaner S, Durmus H, Battaloglu E, Sahin U, Parman Y (2023) A novel biallelic variant in SOD1 causing progressive spastic tetraplegia and axial hypotonia. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 24(5-6): 535-538
Sahin U (2022) Umut Şahin : SUMOylation in health and disease. Life Sci Alliance 5(6)
Mete B, Pekbilir E, Bilge BN, Georgiadou P, Çelik E, Sutlu T, Tabak F, Sahin U (2022) Human immunodeficiency virus type 1 impairs sumoylation. Life Sci Alliance 5(6)
Ergünay T, Ayhan Ö, Celen AB, Georgiadou P, Pekbilir E, Abaci YT, Yesildag D, Rettel M, Sobhiafshar U, Ogmen A, Emre NCT, Sahin U (2022) Sumoylation of Cas9 at lysine 848 regulates protein stability and DNA binding. Life Sci Alliance 5(4) (featured as a cover story)
Sahin U, de Thé H, Lallemand-Breitenbach V (2022) Sumoylation in physiology, pathology and therapy. Cells 11(5), 814
Celen A and Sahin U (2020) Sumoylation on its 25th anniversary : mechanisms, pathology, and emerging concepts. FEBS J. 287(15):3110-3140 (featured as a cover story)
Auvin S, Öztürk H, Abaci YT, Mautino G, Meyer-Losic F, Jollivet F, Bashir T, de Thé H, Sahin U (2019) A molecule inducing androgen receptor degradation and selectively targeting prostate cancer cells. Life Sci Alliance. 2(4): e201800213
Maretzky T, Swendeman S, Mogollon E, Weskamp G, Sahin U, Reiss K, Blobel CP (2017) Characterization of the catalytic properties of the membrane-anchored metalloprotease ADAM9 in cell-based assays. Biochem J. 474(9) : 1467-147
Sahin U, Jollivet F, Berthier C, de Thé H, Lallemand-Breitenbach V (2016) Detection of protein sumoylation in situ by proximity ligation assays. Methods Mol Biol. 1475 :139-150
El Hajj H, Dassouki Z, Berthier C, Raffoux E, Ades L, Legrand O, Sahin U, Tawil N, Salameh A, Zibara K, Darwiche N, Mohty M, Dombret H, Fenaux P, de Thé H, Bazarbachi (2015) Retinoic acid and arsenic trioxide degrade mutated NPM-1 initiating apoptosis of AML cells. Blood. 125(22) :3447-54
Dassouki Z*, Sahin U*#, El Hajj H, Jollivet F, Kfoury Y, Lallemand-Breitenbach V, Hermine O, Bazarbachi A, de Thé H (2015) Adult T-cell Lymphoma Response to Arsenic/Interferon Therapy is Triggered by SUMO/PML/RNF4-dependent Tax Degradation. Blood. 125(3) :474-82 (*co-first authors, # corresponding author)
Sahin U, de Thé H, Lallemand-Breitenbach V (2014) PML Nuclear Bodies : Assembly and Oxidative Stress-sensitive Sumoylation. Nucleus. 5(6) : 499-507
Sahin U, Lallemand-Breitenbach V, de Thé H (2014) PML Nuclear Bodies : Regulation, Function and Therapeutic Perspectives. J Pathol. 234(3) : 289-91
Sahin U#, Lapaquette P, Andrieux A, Faure G, Dejean A (2014) Sumoylation of Human Argonaute-2 at Lysine 402 Regulates its Stability. PLoS One. 9(7) : e102957 doi : 10.1371/journal.pone.0102957 (# corresponding author)
Sahin U, Ferhi O, Carnec X, Zamborlini A, Peres L, Jollivet F, Vitaliano-Prunier A, de Thé H, Lallemand-Breitenbach V (2014) Interferon Controls SUMO Availability via the Lin28 and let-7 Axis to Impede Virus Replication. Nat Commun. 5 : 4187 doi : 10.1038/ncomms5187
Sahin U, Ferhi O, Jeanne M, Benhenda S, Berthier C, Jollivet F, Niwa-Kawakita M, Faklaris O, Setterblad N, de Thé H, Lallemand-Breitenbach V (2014) Oxidative Stress-induced Assembly of PML Nuclear Bodies Controls Sumoylation of Partner Proteins. J Cell Biol. 204(6) : 931-45
Sahin U, Blobel CP (2007) Ectodomain Shedding of the EGF-receptor Ligand Epigen is Mediated by ADAM17. FEBS Lett. 581(1) : 41-4
Sahin U, Weskamp G, Zheng Y, Chesneau V, Horiuchi K, Blobel CP (2006) A Sensitive Method to Monitor Ectodomain Shedding of Ligands of the Epidermal Growth Factor Receptor. Methods Mol Biol. 327 : 99-113
Sahin U, Weskamp G, Kelly K, Zhou HM, Higashiyama S, Peschon J, Hartmann D, Saftig P, Blobel CP (2004) Distinct Roles for ADAM10 and ADAM17 in Ectodomain Shedding of Six EGFR Ligands. J Cell Biol. 164(5) : 769-79
Zhou HM, Weskamp G, Chesneau V, Sahin U, Vortkamp A, Horiuchi K, Chiusaroli R, Hahn R, Wilkes D, Fisher P, Baron R, Manova K, Basson CT, Hempstead B, Blobel CP (2004) Essential Role for ADAM19 in Cardiovascular Morphogenesis. Mol Cell Biol. 24(1) : 96-104