| FACULTY OF ENGINEERING AND NATURAL SCIENCES

Hüveyda BaşağaFaculty of Engineering and Natural SciencesEmeritus Faculty Member(216) 483 9511huveyda@sabanciuniv.edu

Personal Web

http://myweb.sabanciuniv.edu/huveyda/

Jobs

Emeritus Faculty Member

Education

B.Sc. in Pharmacology, Ankara School of Pharmacy, 1975; Ph.D. in Biochemistry, West London Brunel University (England), 1980;

Areas of Interest

Role of oxidative stress and antioxidants on signaling pathways leading to gene expression.

Karakaş, Bahriye and Aka, Yeliz and Giray, Aslı and Temel, Sehime Gulsun and Acikbas, Ufuk and Başağa, Hüveyda and Gul, Ozgur and Kutuk, Ozgur (2021) "Mitochondrial estrogen receptors alter mitochondrial priming and response to endocrine therapy in breast cancer cells", Cell Death Discovery, Vol.7, No.1 (SCI)

Aka, Yeliz and Karakaş, Bahriye and Acikbas, Ufuk and Başağa, Hüveyda and Gül, Özgür and Kütük, Özgür (2021) "Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target", International Journal of Biochemistry and Cell Biology, Vol.137 (SCI)

Birinci, Yelda and Kolkar, Javed and Çetin, Öznur and Başağa, Hüveyda (2020) "Quercetin in the form of a nano-antioxidant (QTiO(2)) provides stabilization of quercetin and maximizes its antioxidant capacity in the mouse fibroblast model", Enzyme and Microbial Technology, Vol.138 (SCI)

Sakul, Arzu and Ozansoy, Mehmet and Elibol, Birsen and Ayla, Şule and Günal, Mehmet Yalçın and Yozgat, Yasemin and Başağa, Hüveyda and Şahin, Kazım and Kazancıoğlu, Rümeysa and Kılıç, Ulkan (2019) "Squalene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice", Turkish Journal of Biology, Vol.43, No.3, 179-188 (SCI)

Timuçin, Ahmet Can and Başağa, Hüveyda and Kütük, Özgür (2019) "Selective targeting of antiapoptotic BCL-2 proteins in cancer", Medicinal Research Reviews, Vol.39, No.1, 146-175 (SCI)

Manda, Gina and Hinescu, Mihail E. and Neagoe, Ionela V. and Ferreira, Luis F. V. and Boscencu, Rica and Vasos, Paul and Başağa, Hüveyda and Cuadrado, Antonio (2018) "Emerging therapeutic targets in oncologic photodynamic therapy", Current Pharmaceutical Design, Vol.24, No.44, 5268-5295 (SCI)

Karakaş, Bahriye and Özmay, Yeliz and Başağa, Hüveyda and Gül, Özgür and Kütük, Özgür (2018) "Distinct apoptotic blocks mediate resistance to panHER inhibitors in HER2+breast cancer cells", Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol.1865, No.8, 1073-1087 (SCI)

Vuruşaner Aktaş, Beyza and Gargiulo, Simona and Testa, Gabriella and Gamba, Paola and Leonarduzzi, Gabriella and Poli, Giuseppe and Başağa, Hüveyda (2018) "The role of autophagy in survival response induced by 27-hydroxycholesterol in human promonocytic cells", Redox Biology, Vol.17, 400-410 (SCI)

Timuçin, Ahmet Can and Başağa, Hüveyda (2017) "Pro-apoptotic effects of lipid oxidation products: HNE at the crossroads of NF-kappa B pathway and anti-apoptotic Bcl-2", Free Radical Biology and Medicine (SI), Vol.111, 209-218 (SCI)

Kütük, Özgür and Aytan, Nurgül and Karakaş, Bahriye and Kurt, Aslı Giray and Açıkbaş, Ufuk and Temel, Sehime Gülsun and Başağa, Hüveyda (2017) "Biphasic ROS production, p53 and BIK dictate the mode of cell death in response to DNA damage in colon cancer cells", PLoS One, Vol.12, No.8 (SCI)

Bodur, Çağrı and Karakaş, Bahriye and Timuçin, Ahmet Can and Tezil, Tuğsan and Başağa, Hüveyda (2016) "AMP-activated protein kinase couples 3-bromopyruvate-induced energy depletion to apoptosis via activation of FoxO3a and upregulation of proapoptotic Bcl-2 proteins", Molecular Carcinogenesis, Vol.55, No.11, 1584-1597 (SCI)

Timuçin, Ahmet Can and Başağa, Hüveyda (2016) "SIRT6 is a positive regulator of aldose reductase expression in U937 and HeLa cells under osmotic stress: in vitro and in silico insights", PLoS One, Vol.11, No.8 (SCI)

David, Iulia Gabriela and Buleandra, Mihaela and Popa, Dana Elena and Bizgan, Ana-Maria Cristina and Moldovan, Zenovia and Badea, Irinel-Adriana and Iorgulescu, Emilia Elena and Tekiner, Tuğçe Ayça and Başağa, Hüveyda (2016) "Voltammetric determination of polyphenolic content as rosmarinic acid equivalent in tea samples using pencil graphite electrodes", Journal of Food Science and Technology, Vol.53, No.6, 2589-2596 (SCI)

Vuruşaner Aktaş, Beyza and Leonarduzzi, Gabriella and Gamba, Paola and Poli, Giuseppe and Başağa, Hüveyda (2016) "Oxysterols and mechanisms of survival signaling", Molecular Aspects of Medicine, Vol.49, 8-22 (SCI)

Vuruşaner, Beyza and Gamba, Paola and Gargiulo, Simona and Testa, Gabriella and Staurenghi, Erica and Leonarduzzi, Gabriella and Poli, Giuseppe and Başağa, Hüveyda (2016) "Nrf2 antioxidant defense is involved in survival signaling elicited by 27-hydroxycholesterol in human promonocytic cells", Free Radical Biology and Medicine, Vol.91, 93-104 (SCI)

Pajares, Marta and Jiménez-Moreno, Natalia and Dias, Irundika H.K. and Debelec, Bilge and Vucetic, Milica and Fladmark, Kari E. and Başağa, Hüveyda and Ribaric, Samo and Milisav, Irina and Cuadrado, Antonio (2015) "Redox control of protein degradation", Redox Biology, Vol.6, 409-420 (SCI)

Timuçin, Ahmet Can and Bodur, Çağrı and Başağa, Hüveyda (2015) "SIRT1 contributes to aldose reductase expression through modulating NFAT5 under osmotic stress: in vitro and in silico insights", Cellular Signalling, Vol.27, No.11, 2160-2172 (SCI)

David, Iulia Gabriela and Bizgan, Ana-Maria Cristina and Popa, Dana Elena and Buleandra, Mihaela and Moldovan, Zenovia and Badea, Irinel Adriana and Tekiner, Tuğçe Ayça and Başağa, Hüveyda and Ciucu, Anton A. (2015) "Rapid determination of total polyphenolic content in tea samples based on caffeic acid voltammetric behaviour on a disposable graphite electrode", Food Chemistry, Vol.173, 1059-1065 (SCI)

Vuruşaner, Beyza and Gamba, Paola and Testa, Gabriella and Gargiulo, Simona and Biasi, Fiorella and Zerbinati, Chiara and Iuliano, Luigi and Leonarduzzi, Gabriella and Başağa, Hüveyda and Poli, Giuseppe (2014) "Survival signaling elicited by 27-hydroxycholesterol through the combined modulation of cellular redox state and ERK/Akt phosphorylation", Free Radical Biology and Medicine, Vol.77, 376-385 (SCI)

Tezil, Tuğsan and Başağa, Hüveyda (2014) "Modulation of cell death in age related diseases", Current Pharmaceutical Design, Vol.20, No.18, 3052-3067 (SCI)

Tekiner, Tugce Ayca and Başağa, Hüveyda (2013) "Role of microRNA deregulation in breast cancer cell chemoresistance and stemness", Current Medicinal Chemistry, Vol.20, No.27, 3358-3369 (SCI)

Bodur, Çağrı and Kütük, Özgür and Karslı, Gizem and Isimjan, Tayirjan T. and Harrison, Paul and Başağa, Hüveyda (2013) "Pramanicin analog induces apoptosis in human colon cancer cells: critical roles for Bcl-2, Bim, and p38 MAPK signaling", PLoS One, Vol.8, No.2 (SCI)

Bodur, Çağrı and Kütük, Özgür and Tezil, Tuğsan and Başağa, Hüveyda (2012) "Inactivation of Bcl-2 through I kappa B kinase (IKK)-dependent phosphorylation mediates apoptosis upon exposure to 4-hydroxynonenal (HNE)", Journal of Cellular Physiology, Vol.227, No.11, 3556-3565 (SCI)

Tezil, Tuğsan and Bodur, Çağrı and Kütük, Özgür and Başağa, Hüveyda (2012) "IKK-beta mediates chemoresistance by sequestering FOXO3; a critical factor for cell survival and death", Cellular Signalling, Vol.24, No.6, 1361-1368 (SCI)

Bodur, Çağrı and Başağa, Hüveyda (2012) "Bcl-2 inhibitors: emerging drugs in cancer therapy", Current Medicinal Chemistry (CMC), Vol.19, No.12, 1804-1820 (SCI)

Vuruşaner, Beyza and Poli, Giuseppe and Başağa, Hüveyda (2012) "Tumor suppressor genes and ROS: complex networks of interactions", Free Radical Biology and Medicine, Vol.52, No.1, 7-18 (SCI)

Timuçin, Can and Gül, Özgür and Kütük, Özgür and Başağa, Hüveyda (2012) "Antibody array-based immunosensor for detecting cardiovascular disease risk markers", Journal of Immunoassay and Immunochemistry, Vol.33, No.3, 275-290 (SCI)

Negre-Salvayre, Anne and Auge, Nathalie and Ayala, Victoria and Başağa, Hüveyda and Boada, Jordi and Brenke, Rainer and Chapple, Sarah and Cohen, Guy and Feher, Janos and Grune, Tilman and Lengyel, Gabriella and Mann, Giovanni E. and Pamplona, Reinald and Poli, Giuseppe and Portero-Otin, Manuel and Riahi, Yael and Salvayre, Robert and Sasson, Shlomo and Serrano, Jose and Shamni, Ofer and Siems, Werner and Siow, Richard C. M. and Wiswedel, Ingrid and Zarkovic, Kamelija and Zarkovic, Neven (2010) "Pathological aspects of lipid peroxidation", Free Radical Research (Sp. Iss. SI), Vol.44, No.10, 1125-1171 (SCI)

Kütük, Özgür and Temel, Sehime Gülsun and Tolunay, Sahsine and Başağa, Hüveyda (2010) "Aven blocks DNA damage-induced apoptosis by stabilising Bcl-xL", European Journal of Cancer, Vol.46, No.13, 2494-2505 (SCI)

Arısan, Elif Damla and Kütük, Özgür and Tezil, Tuğsan and Bodur, Çağrı and Telci, Dilek and Başağa, Hüveyda (2010) "Small inhibitor of Bcl-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating Bcl-2 family members in MDA-MB-231 breast cancer cells", Breast Cancer Research and Treatment, Vol.119, No.2, 271-281 (SCI)

Telci, Dilek and Collighan, Russell John and Başağa, Hüveyda and Griffin, Martin (2009) "Increased TG2 expression can result in induction of transforming growth factor beta 1, causing increased synthesis and deposition of matrix proteins, which can be regulated by nitric oxide", Journal of Biological Chemistry, Vol.284, No.43, 29547-29558 (SCI)

Kütük, Özgür and Arısan, Elif Damla and Tezil, Tuğsan and Shoshan, Maria C. and Başağa, Hüveyda (2009) "Cisplatin overcomes Bcl-2-mediated resistance to apoptosis via preferential engagement of Bak: critical role of Noxa-mediated lipid peroxidation", Carcinogenesis, Vol.30, No.9, 1517-1527 (SCI)

Hernlund, Emma and Kütük, Özgür and Başağa, Hüveyda and Linder, Stig and Panaretakis, Theocharis and Shoshan, Maria (2009) "Cisplatin-induced nitrosylation of p53 prevents its mitochondrial translocation", Free Radical Biology and Medicine, Vol.46, No.12, 1607-1613 (SCI)

Telci, Dilek and Wang, Zhuo and Li, Li and Verderio, Elisabetta A. M. and Humphries, Martin J. and Baccarini, Manuela and Başağa, Hüveyda and Griffin, Martin (2008) "Fibronectin-tissue transglutaminase matrix rescues RGD-impaired cell adhesion through Syndecan-4 and β1 Integrin co-signaling", The Journal of Biological Chemistry, Vol.283, No.30, 20937-20947 (SCI)

Kallempudi, Sreenivasa Saravan and Gül, Özgür and Başağa, Hüveyda and Sezerman, Uğur and Gürbüz, Yaşar (2008) "Label-free biosensors for the detection and quantification of cardiovascular risk markers", Journal of Sensor Letters, Vol.6, 1-5 (SCI)

Gül, Özgür and Calay, Ediz Süha and Sezerman, Uğur and Başağa, Hüveyda and Gürbüz, Yaşar (2007) "Sandwich-type, antibody microarrays for the detection and quantification of cardiovascular risk markers", Sensors and actuators. B, Chemical, Vol.125, No.2, 581-588 (SCI)

Kütük, Özgür and Başağa, Hüveyda (2007) "Apoptosis signalling by HNE: a role For JNK-c-Jun/AP-1 pathway", Redox Report, Vol.12, No.1-2, 30-34 (SCI)

Arslan, Mehmet Alper and Kütük, Özgür and Başağa, Hüveyda (2006) "Protein kinases as drug targets in cancer", Current Cancer Drug Targets, Vol.6, No.7, 623-634 (SCI)

Kütük, Özgür and Başağa, Hüveyda (2006) "Bcl-2 protein family: Implications in vascular apoptosis and atherosclerosis", Apoptosis, Vol.11, No.10, 1661-1675 (SCI)

Kütük, Özgür and Pedrech, A. and Harris, P. and Başağa, Hüveyda (2005) "Pramanicin induces apoptosis in Jurkat leukemia cells; a role for JNK, p38 and caspase activation", Apoptosis, Vol.10, No.3, 597-609 (SCI)

Arslan, Mehmet Alper and Başağa, Hüveyda and Göktuna, Serkan İsmail (2005) "Signaling pathways as drug targets in cancer", Advances in Molecular Medicine, supplement, Vol.1, No.2, 69-74 (NA)

Kütük, Özgür and Adli, Mazhar and Poli, Giuseppe and Başağa, Hüveyda (2004) "Resveratrol protects against 4-HNE induced oxidative stress and apoptosis in Swiss 3T3 fibroblasts", Biofactors, Vol.20, No.1, 1-10 (SCI)

Kütük, Özgür and Başağa, Hüveyda (2004) "Aspirin inhibits TNF alpha- and IL-1-induced NF-kappa B activation and sensitizes HeLa cells to apoptosis", Cytokine, Vol.25, No.5, 229-237 (SCI)

Kütük, Özgür and Başağa, Hüveyda (2003) "Aspirin prevents apoptosis and NF-kappa B activation induced by H2O2 in HeLa cells", Free Radical Research, Vol.37, No.12, 1267-1276 (SCI)

Kütük, Özgür and Başağa, Hüveyda (2003) "Inflammation meets oxidation: NF-kappa B as a mediator of initial lesion development in atherosclerosis", Trends in molecular medicine, Vol.9, No.12, 549-557 (SCI)

Onat, D. and Boscoboinik, D. and Azzi, A. and Başağa, Hüveyda (1999) "Effect of alpha-tocopherol and silibin dihemisuccinate on the proliferation of human skin fibroblasts", Biotechnology and Applied Biochemistry, Vol.29, No.part 3, 213-215 (SCI)